کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10145641 | 1646365 | 2019 | 54 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluating the effect of chitosan layer on bioaccessibility and cellular uptake of curcumin nanoemulsions
ترجمه فارسی عنوان
ارزیابی اثر لایه های کیتوزان بر قابلیت زیستی و جذب سلولی نانوذرات کورکومین
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
Curcumin nanoemulsions stabilized by whey protein isolate were successfully developed using high-pressure homogenization. The effect of a chitosan layer deposition using the layer-by-layer technique on nanoemulsions' stability was evaluated during storage conditions, as well as during gastrointestinal tract passage. Lipids' hydrolysis and curcumin bioaccessibility was assessed using a dynamic gastrointestinal model (simulating the stomach, duodenum, jejunum and ileum) and the cytotoxicity, cellular antioxidant activity and permeability analyses were carried out using Caco-2â¯cells. Results showed that both nanosystems were stable during one month of storage and at stomach pH conditions, whereas creaming and phase separation occurred at intestine pH conditions. The addition of a chitosan layer increased curcumin bioaccessibility, whereas cellular antioxidant activity studies revealed that nanoemulsions and multilayer nanoemulsions exhibited 9 and 10 times higher antioxidant capacity at the cellular level, respectively, when compared to free curcumin. Permeability assays showed that the use of a chitosan layer significantly increased the apparent permeability coefficient of curcumin through Caco-2â¯cells by 1.55-folds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food Engineering - Volume 243, February 2019, Pages 89-100
Journal: Journal of Food Engineering - Volume 243, February 2019, Pages 89-100
نویسندگان
Hélder D. Silva, EliÅ¡ka BeldÃková, Joana Poejo, LuÃs Abrunhosa, Ana Teresa Serra, Catarina M.M. Duarte, TomáÅ¡ Brányik, Miguel A. Cerqueira, Ana C. Pinheiro, António A. Vicente,