کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10149393 | 1646742 | 2019 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques
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کلمات کلیدی
CAFA2ACynomolgus macaqueNHPLMATSTREMNREMElectroencephalogram - الکتروانسفالوگرافیelectromyogram - الکترومیوگرافیEMG - الکترومیوگرافیWake after sleep onset - بیدار شدن بعد از خوابrapid eye movement - حرکت سریع چشمnon-rapid eye movement - حرکت سریع چشم نیستstandard error of mean - خطای استاندارد میانگینSleep - خوابROL - رولSleep onset latency - زمان تأخیر خوابtotal sleep time - زمان خواب کلSol - سلIntramuscular - عضلانیLocomotor activity - فعالیت locomotorSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیi.m. - من هستم.non-human primate - نخستیسانان غیرانسانیEEG - نوار مغزیWASO - واسهCaffeine - کافئین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Most preclinical sleep studies are conducted in nocturnal rodents that have fragmented sleep in comparison to humans who are primarily diurnal, typically with a consolidated sleep period. Consequently, we sought to define basal sleep characteristics, sleep/wake architecture and electroencephalographic (EEG) activity in a diurnal non-human primate (NHP) to evaluate the utility of this species for pharmacological manipulation of the sleep/wake cycle. Adult, 9-11â¯y.o. male cynomolgus macaques (n = 6) were implanted with telemetry transmitters to record EEG and electromyogram (EMG) activity and Acticals to assess locomotor activity under baseline conditions and following injections either with vehicle or the caffeine (CAF; 10â¯mg/kg, i.m.) prior to the 12â¯h dark phase. EEG/EMG recordings (12-36â¯h in duration) were analyzed for sleep/wake states and EEG spectral composition. Macaques exhibited a sleep state distribution and architecture similar to previous NHP and human sleep studies. Acute administration of CAF prior to light offset enhanced wakefulness nearly 4-fold during the dark phase with consequent reductions in both NREM and REM sleep, decreased slow wave activity during wakefulness, and increased higher EEG frequency activity during NREM sleep. Despite the large increase in wakefulness and profound reduction in sleep during the dark phase, no sleep rebound was observed during the 24â¯h light and dark phases following caffeine administration. Cynomolgus macaques show sleep characteristics, EEG spectral structure, and respond to CAF in a similar manner to humans. Consequently, monitoring EEG/EMG by telemetry in this species may be useful both for basic sleep/wake studies and for pre-clinical assessments of drug-induced effects on sleep/wake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Sleep and Circadian Rhythms - Volume 6, January 2019, Pages 9-23
Journal: Neurobiology of Sleep and Circadian Rhythms - Volume 6, January 2019, Pages 9-23
نویسندگان
Anushka V. Goonawardena, Stephen R. Morairty, Gabriel A. Orellana, Adrian R. Willoughby, Tanya L. Wallace, Thomas S. Kilduff,