کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10212509 | 1673251 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrastructural changes in peripheral blood leukocytes in α-synuclein knockout mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Effects of α-synuclein deficiency on cellular blood components have not been extensively investigated. This study evaluated ultrastructural changes of leukocytes in α-synuclein knockout (KO) mice using electron microscopy (EM). The following ultrastructural characteristics were quantified in leukocytes: mitochondria, primary granules, specific granules (SG), Golgi apparatus (GA), inclusions, rough-endoplasmic reticulum (RER), smooth-endoplasmic reticulum (SER), and cellular projections (CP). EM showed increased numbers or amounts of SG, inclusions, and SER in KO group (5.3â¯Â±â¯4.5 in WT vs. 14.1â¯Â±â¯10.3 in KO, pâ¯=â¯0.02; 0.4â¯Â±â¯0.9 in WT vs. 3.2â¯Â±â¯2.8 in KO, pâ¯=â¯0.007; and 7.7â¯Â±â¯6.7 in WT vs. 17.7â¯Â±â¯12.2 in KO, pâ¯=â¯0.03, respectively). Although CP number was not significantly different between the two groups (13.4â¯Â±â¯5.3 in WT vs. 16.3â¯Â±â¯7.5 in KO, pâ¯=â¯0.32), their size and shapes were altered in KO mice. Notably, findings occurred in the setting of significant lymphopenia. α-Synuclein deficiency leads to changes in size and shape of secretory particles and increases in SER, SG, and inclusions, indicating a potential role for α-synuclein in vesicular trafficking in leukocytes. Further studies are needed to elucidate functions mediated by α-synuclein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 73, November 2018, Pages 33-37
Journal: Blood Cells, Molecules, and Diseases - Volume 73, November 2018, Pages 33-37
نویسندگان
Hammad Tashkandi, Afshin Shameli, Clifford V. Harding, Robert W. Maitta,