کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
103437 161380 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hair analysis of an unusual case of Chloroquine intoxication
ترجمه فارسی عنوان
تحلیل مو از یک مورد غیرمعمول مسمومیت کلروکین
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Chloroquine was quantitated in hair in fatal poisoning case.
• High concentration (211 ng/mg) of chloroquine was found in deceased’s hair.
• Kidney contained 37.3 mg/kg chloroquine.
• These findings strongly suggested chloroquine intoxication.

A dead body of middle aged man was exhumed from 6.5 month earth-grave. Autopsy findings were non-specific as the body was completely putrefied. Deceased’s scalp hair and kidney was sent for toxicological analysis. Hair sample (50 mg) was incubated with 1 M NaOH (2 ml). Chloroquine was detected in hair and kidney during basic drug screen performed on GC/MS. For confirmation and quantitation, chloroquine was extracted using Hypersep verify CX SPE cartridges while mass detector was operated in SIM mode using the ions of m/z 245.0, 290.1, 319.0 for chloroquine while ions of m/z 260 and 455 were monitored for nalorphine (internal standard). Chloroquine was present in high concentration in hair (211 ng/mg) as well as in kidney (37.3 mg/kg). Moreover, chloroquine was not detected in the wash solvents, suggesting ingestion of the drug rather than an external contamination of hair. These findings strongly suggested the acute exposure of higher doses of chloroquine to the deceased before death.

A SIM chromatogram of chloroquine and IS obtained from extract of the deceased’s hair.Figure optionsDownload high-quality image (116 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Legal Medicine - Volume 19, March 2016, Pages 5–10
نویسندگان
, , , , , , ,