کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10592728 981798 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drug discovery considerations in the development of covalent inhibitors
ترجمه فارسی عنوان
ملاحظات کشف مواد مخدر در توسعه مهارکننده های کووالانتی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
In recent years, the number of drug candidates with a covalent mechanism of action progressing through clinical trials or being approved by the FDA has increased significantly. And as interest in covalent inhibitors has increased, the technical challenges for characterizing and optimizing these inhibitors have become evident. A number of new tools have been developed to aid this process, but these have not gained wide-spread use. This review will highlight a number of methods and tools useful for prosecuting covalent inhibitor drug discovery programs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 1, 1 January 2014, Pages 33-39
نویسندگان
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