کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1066813 1485976 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice
ترجمه فارسی عنوان
راستش تصور آن چنانی جد قرار گرفتن در معرض اتانول باعث کندی responsivity محور هیپوتالاموس هیپوفیز آدرنال و استرس ناشی از مصرف بیش از حد مایع در موش سوری نر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Paternal alcohol blunts acute HPA-axis responsivity selectively in male offspring.
• Paternal alcohol has no effect on stress-evoked ethanol-drinking in male offspring.
• Paternal alcohol prevents stress-induced behavior (polydipsia-like fluid intake) in male offspring.

A growing number of environmental insults have been shown to induce epigenetic effects that persist across generations. For instance, paternal preconception exposures to ethanol or stress have independently been shown to exert such intergenerational effects. Since ethanol exposure is a physiological stressor that activates the hypothalamic-pituitary-adrenal (HPA) axis, we hypothesized that paternal ethanol exposure would impact stress responsivity of offspring. Adult male mice were exposed to chronic intermittent vapor ethanol or control conditions for 5 weeks before being mated with ethanol-naïve females to produce ethanol (E)- and control (C)-sired offspring. Adult male and female offspring were tested for plasma corticosterone (CORT) levels following acute restraint stress and the male offspring were further examined for stress-evoked 2-bottle choice ethanol-drinking. Paternal ethanol exposure blunted plasma CORT levels following acute restraint stress selectively in male offspring; females were unaffected. In a stress-evoked ethanol-drinking assay, there was no effect of stress on ethanol consumption. However, C-sired males exhibited increased total fluid intake (polydipsia) in response to stress while E-sired males were resistant to this stress-induced phenotype. Taken together, these data suggest that paternal ethanol exposure imparts stress hyporesponsivity to male offspring.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 53, June 2016, Pages 19–25
نویسندگان
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