کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1066864 948848 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of acute ethanol administration on zebrafish tail-beat motion
ترجمه فارسی عنوان
تأثیر تجویز اتانول حاد بر حرکات tail-beat گورخرماهی
کلمات کلیدی
اتانول؛ انتقال؛ فرکانس ضربه؛ گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Zebrafish exhibit a burst-and-coast swimming style.
• A shape-tracking algorithm is used to study zebrafish tail beat motion.
• The effect of ethanol exposure on motor functions is investigated.
• Ethanol administration modulates the tail beat amplitude and frequency.
• High ethanol exposure is associated with slowness and impaired swimming.

Zebrafish is becoming a species of choice in neurobiological and behavioral studies of alcohol-related disorders. In these efforts, the activity of adult zebrafish is typically quantified using indirect activity measures that are either scored manually or identified automatically from the fish trajectory. The analysis of such activity measures has produced important insight into the effect of acute ethanol exposure on individual and social behavior of this vertebrate species. Here, we leverage a recently developed tracking algorithm that reconstructs fish body shape to investigate the effect of acute ethanol administration on zebrafish tail-beat motion in terms of amplitude and frequency. Our results demonstrate a significant effect of ethanol on the tail-beat amplitude as well as the tail-beat frequency, both of which were found to robustly decrease for high ethanol concentrations. Such a direct measurement of zebrafish motor functions is in agreement with evidence based on indirect activity measures, offering a complementary perspective in behavioral screening.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 49, Issue 7, November 2015, Pages 721–725
نویسندگان
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