Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells

- Atorvastatin exerts direct regulatory effects on TLR4 protein and mRNA expression.
- Our study show that statin treatment could reduce the LPS-induced NF-κB.
- Interactions with innate immunity may serve as one of the pleiotropic mechanisms of statins.