کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10999945 1419835 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zein/diclofenac sodium coprecipitation at micrometric and nanometric range by supercritical antisolvent processing
ترجمه فارسی عنوان
زین / دیکلوفناک سدیم در محدوده میکرومتر و نانومتر توسط پردازش ضد حلال فوق بحرانی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
چکیده انگلیسی
In this work, the supercritical antisolvent (SAS) process is proposed to coprecipitate zein with diclofenac sodium (a model drug). In the first part of this paper, the proper conditions, in terms of pressure, temperature and concentration, for the attainment of zein microparticles, were detected. At 90 bar, 40 °C and 50 mg/mL, microparticles with a mean diameter of 4.19 μm were obtained. The coprecipitation with diclofenac sodium at different polymer/drug ratio and concentration in the liquid solution was successfully performed and, with the support of the drug release analyses, the coprecipitation mechanisms (both in the case of microparticles and nanoparticles formation) were postulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of CO2 Utilization - Volume 27, October 2018, Pages 366-373
نویسندگان
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