NLRP3 inflammasome activation in liver cirrhotic patients

Plasma IL-1β and IL-18 levels were higher in plasma in patients with liver cirrhosis than in control subjects, and plasma IL-18 levels were significantly positively associated with Child-Pugh classification and IL-1β levels. In addition, NLRP3 and cleaved caspase-1 expression were increased in the livers of patients with cirrhosis.