کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11015572 | 1782694 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamics of alternative polyadenylation in human preimplantation embryos
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Alternative polyadenylation (APA) affects the length of the 3â² untranslated region (3â²-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3â²-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3â²-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3â²-UTRs tended to become longer, and gene expression was negatively correlated with 3â²-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3â²-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 504, Issue 4, 12 October 2018, Pages 727-733
Journal: Biochemical and Biophysical Research Communications - Volume 504, Issue 4, 12 October 2018, Pages 727-733
نویسندگان
Jen-Yun Chang, Wen-Hsuan Yu, Hsueh-Fen Juan, Hsuan-Cheng Huang,