کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11016342 | 1777900 | 2019 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Visualizing hydrogen peroxide in Parkinson's disease models via a ratiometric NIR fluorogenic probe
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Parkinson's disease (PD) is a neurological disorder which will significantly overwhelm the life for the patient. Numerous studies have proved that hydrogen peroxide plays an important role in the pathogenesis of PD. To detect hydrogen peroxide in PD in live, here we report the design and synthesis of a new ratiometric and NIR fluorescence probe (NIR-HP1) for hydrogen peroxide, utilizing an excited state intramolecular proton transfer strategy to control the fluorescence. NIR-HP1 showed a highly selective ratiometric response to hydrogen peroxide over other reactive oxygen/nitrogen species, biothiols and various ions in aqueous solution at physiological pH. The observed pseudo-first-order rate constant for the reaction of NIR-HP1 with hydrogen peroxide was calculated to be 0.042 sâ1. The detection limit of this sensor for hydrogen peroxide was 0.27âμM. Moreover, NIR-HP1 worked well in living systems for hydrogen peroxide sensing as displayed by confocal fluorescence microscopy imaging, indicating potential application in PD study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 279, 15 January 2019, Pages 38-43
Journal: Sensors and Actuators B: Chemical - Volume 279, 15 January 2019, Pages 38-43
نویسندگان
Yi Liu, Lei Bai, Yihao Li, Yun Ni, Chenqi Xin, Chengwu Zhang, Jinhua Liu, Zhipeng Liu, Lin Li, Wei Huang,