کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11025674 1666537 2018 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to a glyphosate-based herbicide formulation, but not glyphosate alone, has only minor effects on adult rat testis
ترجمه فارسی عنوان
قرار گرفتن در معرض یک فرمولاسیون علف کش مبتنی بر گلیفوزیت، اما نه فقط گلای فسات، تنها اثرات جزئی بر روی بیضه های موش بالغ دارد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Glyphosate has been suggested to be an endocrine disrupting chemical capable of disrupting male reproduction. There are conflicting data, however, with studies reporting effects from exposure to either glyphosate alone or to herbicide formulations, making comparisons difficult. We assessed rat testis histopathology and androgen function following two weeks exposure to either glyphosate at 2.5 and 25 mg/kg bw/day (5x and 50x Acceptable Daily Intake, ADI, respectively), or equivalent high dose of glyphosate in a herbicide formulation; Glyfonova. We observed no significant effects on testes or testosterone synthesis in rats exposed to glyphosate. Limited effects were observed in rats exposed to Glyfonova, with a small upregulation of the steroidogenic genes Cyp11a1 and Cyp17a1. We conclude that glyphosate alone has no effect on adult rat testis at exposure levels up to 25 mg/kg bw/day. Glyfonova induced only minor effects on steroidogenic gene expression, likely caused by additives other than glyphosate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 82, December 2018, Pages 25-31
نویسندگان
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