کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11025936 1666468 2018 82 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pan-HER-targeted approach for cancer therapy: Mechanisms, recent advances and clinical prospect
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Pan-HER-targeted approach for cancer therapy: Mechanisms, recent advances and clinical prospect
چکیده انگلیسی
The Human Epidermal Growth Factor Receptor family is composed of 4 structurally related receptor tyrosine kinases that are involved in many human cancers. The efficacy and safety of HER inhibitors have been compared in a wide range of clinical trials, suggesting the superior inhibitory ability of multiple- HER-targeting blockade compared with single receptor antagonists. However, many patients are currently resistant to current therapeutic treatment and novel strategies are warranted to conquer the resistance. Thus, we performed a critical review to summarize the molecular involvement of HER family receptors in tumour progression, recent anti-HER drug development based on clinical trials, and the potential resistance mechanisms of anti-HER therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 439, 28 December 2018, Pages 113-130
نویسندگان
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