کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11263948 1555895 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From recognition to execution - the HCMV Pentamer from receptor binding to fusion triggering
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
From recognition to execution - the HCMV Pentamer from receptor binding to fusion triggering
چکیده انگلیسی
The β-herpesvirus human cytomegalovirus (HCMV) is the leading viral cause of neonatal developmental disabilities. In HCMV, the conserved herpesvirus glycoprotein B (gB) mediates membrane fusion between the viral and host cell membranes, whereas the trimeric gH/gL/gO or the pentameric gH/gL/UL128/UL130/UL31A complexes (Pentamer) bind to cell-specific receptors and provide the triggering signal to gB. Recent structural and functional studies have provided new insights into Pentamer structure, conformational flexibility, location of epitopes for neutralizing antibodies and potential binding sites for cell surface receptors. Together, these data suggest a model where receptor binding triggers a conformational change in Pentamer, allowing it to interact with gB and initiate the membrane fusion process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Virology - Volume 31, August 2018, Pages 43-51
نویسندگان
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