کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1192556 1492226 2016 8 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
ESI FT-MS and DFT studies of aqueous Au(I) complexes with cysteine and its disulfide form cystine
ترجمه فارسی عنوان
مطالعات ESI FT-MS و DFT از ترکیبات Au (I) آبی با سیتستین و دیسولفید آن از سیستین
کلمات کلیدی
ترکیبات طلا (I) سیستین؛ ESI FT طیف سنجی جرمی؛ CID؛ M06؛ TD-DFT
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• FT-MS experiments of aqueous AuCl3:cysteine capture cystine formation and Au-cystine complexation.
• Results from CID and IRMPD fragmentation experiments confirm identity of [Au(CySSCy)(CySH)n]+ complexes with n = 0–2.
• Concentration- and time-dependent ESI–MS experiments with [Au(CySSCy)(CuSH)n]+ provide a direct molecular link between gas and solution phase speciation.
• [Au(CySSCy)(CySH)n]+ complexes are unstable and lost from solution within a short time period.
• Theoretical DFT complexation energies for [Au(CySSCy)(CySH)n]+ mirror ion signal trends measured by FT-MS.

Aqueous complexes of [Au(CySSCy)(CySH)n]+ containing gold(I), cysteine (CySH) and the disulfide cystine (CySSCy) have been examined by electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry, and the identities of individual Au complexes have been confirmed by infrared multiphoton dissociation (IRMPD)- and collision-induced dissociation (CID) experiments. Results from positive-mode ESI–MS experiments show that the aqueous Au(III)/cysteine system has a strong tendency to auto-oxidize toward cystine and form aurous-disulfide complexes of the type [Au(CySSCy)]+ and [Au(CySSCy)(CySH)n]+. An examination of the concentration- and time-dependent complexation behavior of Au(I) with CySSCy and CySH shows that the abundance of [Au(CySSCy)(CySH)]+ and [Au(CySSCy)(CySH)2]+ increases with increasing ESI solution concentration, consistent with the aqueous ionization of cysteine at pKa1 = 1.92. In general, the response of individual ESI mass spectra of [Au(CySSCy)(CySH)n]+ to changes in solution concentration is indicative of a direct correlation between gas-phase and aqueous Au speciation, a feature that is likely rooted in gold complexation processes occurring in solution prior to electrospraying. Finally, equilibrium geometries of Au(I) complexes with cystine and cysteine have been predicted using M06 and PCM/TD-DFT calculations, and these results have been employed to predict stepwise complexation energies of [Au(CySSCy)(CySH)n]+ and to pinpoint the most important UV–vis absorption features in aqueous solution.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Mass Spectrometry - Volume 406, 1 August 2016, Pages 12–19
نویسندگان
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