کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219539 1494543 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-inflammatory and anti-proliferative activities of natural and sulphonated polysaccharides from Pleurotus eryngii
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Anti-inflammatory and anti-proliferative activities of natural and sulphonated polysaccharides from Pleurotus eryngii
چکیده انگلیسی


• Polysaccharides were extracted from Pleurotus eryngii (PEPS) and sulphonated.
• Both ROS and NO inhibition activities of PEPS were improved after sulphonation.
• Anti-inflammatory activity of PEPS on RAW264.7 cells was improved after sulphonation.
• Anti-proliferative activity of PEPS on Caco-2 cells was improved after sulphonation.
• Anti-proliferative activity of PEPS on HepG2 cells was improved after sulphonation.

Polysaccharides were extracted from Pleurotus eryngii (PEPS) and sulphonated. Anti-inflammatory activities of PEPS and sulphonated PEPS (S.PEPS) were tested on RAW264.7 macrophages in four experimental models. Cytokines of IL-1β, IL-6, IL-10, and TNF-α were quantified by ELISA. Cytokine secretion ratios (IL-1β/IL-10, IL-6/IL-10, and TNF-α/IL-10) were significantly decreased by PEPS and S.PEPS treatments in a dose dependent manner in all four experimental models. Anti-inflammatory activity of S.PEPS was significantly stronger than that of PEPS, and the S.PEPS exhibited stronger reactive oxygen species (ROS) and nitric oxide (NO) inhibition activities compared with those of PEPS. Additionally, S.PEPS also had significantly stronger anti-proliferative activities on both Caco-2 and HepG2 cells compared with those of PEPS. Results indicated that sulphonation improved the anti-inflammatory and anti-proliferative activities of PEPS significantly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 23, May 2016, Pages 80–86
نویسندگان
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