کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1220083 | 1494555 | 2014 | 11 صفحه PDF | دانلود رایگان |
• HPLC profiling indicated that MEBG contained alliin.
• MEBG suppressed the body weight in obese rats fed a HFD.
• MEBG inhibited the liver size, perirenal, and epididymal fat in obese rats.
• MEBG suppressed the serum lipid profile in obese rats.
• MEBG decreased the lipogenesis and increased the fatty acid β-oxidation.
The objective of this study was to determine if methanolic extract of black garlic (MEBG) has antiobesity effects via regulating lipid metabolism in an animal model. The results indicate that supplementation with MEBG decreased the final body weight; the relative masses of the liver and fat tissues; serum triacylglyceride levels; and hepatic oxidative stress and increased faecal lipid contents in HFD rats. Supplementation with MEBG upregulated AMPK, FOXO1, Sirt1, ATGL, HSL, perilipin, ACO, CPT-1, and UCP1 in the adipose tissues of HFD rats, whereas it downregulated CD36. Meanwhile, MEBG upregulated adiponectin and downregulated PAI-1, resistin, TNF-α, and GLUT4 in the adipose tissues of HFD rats. Regarding hepatic gene expression, MEBG upregulated AMPK, Sirt1, and PPARα but downregulated SREBP-1c, ACC, FAS, and SCD1. Therefore, MEBG can be developed as a potential nutraceutical ingredient for the prevention of obesity in a niche market.
Journal: Journal of Functional Foods - Volume 9, July 2014, Pages 98–108