کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1227477 | 1494864 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantification of neurotransmitters and metabolically related compounds at glassy carbon electrodes modified with bamboo-like carbon nanotubes dispersed in double stranded DNA
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
This work reports the application of glassy carbon electrodes (GCE) modified with bamboo-like carbon nanotubes (bCNT) dispersed in calf-thymus double-stranded DNA (dsDNA) (GCE/bCNT-dsDNA) for the highly sensitive and selective quantification of neurotransmitters and metabolically related compounds by Adsorptive Stripping. Dopamine (Do) was quantified in the presence of its most important metabolite, 3,4-dihydroxyphenylacetic acid (dopac), while normetanephrine (NM) was determined in the presence of its precursor norepinephrine (NE). The accumulation of the analytes was performed at open circuit potential and the quantification was carried out, after medium exchange, in a 0.200 M acetate buffer solution pH 5.0 using Differential Pulse Voltammetry. The sensitivity for Do in the presence of 1.0 Ã 10â 5 M dopac was (7.1 ± 0.2) Ã 105 μAMâ 1, (just 7.0% higher than the one obtained for Do alone), the detection limit was 68 nM, and the linear range 5.0 Ã 10â 7 M-7.0 Ã 10â 6 M. The sensitivities for NM in the absence and presence of NE were (2.8 ± 0.1) Ã 104 μAMâ 1 and (2.6 ± 0.2) Ã 104 μAMâ 1, with a linear range between 1.0 Ã 10â 6 and 2.0 Ã 10â 5 M, and a detection limit of 0.5 μM. The platform was successfully used for the quantification of Do and NM in enriched human urine samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 130, January 2017, Pages 40-46
Journal: Microchemical Journal - Volume 130, January 2017, Pages 40-46
نویسندگان
Alejandro Gutiérrez, Emiliano N. Primo, Marcos EguÃlaz, Concepción Parrado, MarÃa D. Rubianes, Gustavo A. Rivas,