کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1229995 1495198 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cu(I) complexes of bis(methyl)(thia/selena) salen ligands: Synthesis, characterization, redox behavior and DNA binding studies
ترجمه فارسی عنوان
مجتمع های بیس مس (I) (متیل) (THIA / سلنا) لیگاندهای salen: سنتز، شناسایی، رفتار ردوکس و DNA مطالعات اتصال
کلمات کلیدی
THIA / سلنا-salen؛ مس (I) مجتمع؛ ولتامتری چرخه ای؛ اتصال DNA
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی

Mononuclear cuprous complexes 1 and 2, [{CH3E(o-C6H4)CH = NCH2}2Cu]ClO4; E = S/Se, have been synthesized by the reaction of bis(methyl)(thia/selena) salen ligands and [Cu(CH3CN)4]ClO4. Both the products were characterized by elemental analysis, ESI-MS, FT-IR, 1H/13C/77Se NMR, and cyclic voltammetry. The complexes possess tetrahedral geometry around metal center with the N2S2/N2Se2 coordination core. Cyclic voltammograms of complexes 1 and 2 displayed reversible anodic waves at E1/2 = + 0.08 V and + 0.10 V, respectively, corresponding to the Cu(I)/Cu(II) redox couple. DNA binding studies of both the complexes were performed applying absorbance, fluorescence and molecular docking techniques. Competitive binding experiment of complexes with ct-DNA against ethidium bromide is performed to predict the mode of binding. The results indicate the groove binding mode of complexes 1 and 2 to DNA. The binding constants revealed the strong binding affinity of complexes towards ct-DNA.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 171, 15 January 2017, Pages 18–24
نویسندگان
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