کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1253979 | 971320 | 2016 | 4 صفحه PDF | دانلود رایگان |
In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves of Nicotiana tabacum resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B (1 and 2), along with four known sesquiterpene derivatives (3–6). Structural elucidation of 1 and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1–6 were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%–29.2%.
Two new sesquiterpenes (1 and 2) were isolated from the leaves of Nicotiana tabacum and exhibited high anti-TMV activities with inhibition rates of 36.7% and 45.6%, respectively.Figure optionsDownload as PowerPoint slide
Journal: Chinese Chemical Letters - Volume 27, Issue 5, May 2016, Pages 753–756