A synthesis of spirofuran-indenoquinoxalines via isocyanid-based one-pot four-component reaction

A simple and versatile procedure for the combinatorial synthesis of (Z)-dialkyl-5-(alkylimino)-5H-spiro[furan-2,11′-indeno[1,2-b]quinoxaline]-3,4-dicarboxylates via the catalyst-free one-pot four-component reaction of ninhydrin, benzene-1,2-diamines, dialkyl acetylenedicarboxylates and isocyanides is described.

A synthesis of (Z)-dialkyl-5-(alkylimino)-5H-spiro[furan-2,11′-indeno[1,2-b]quinoxaline]-3,4- dicarboxylates via one-pot four-component reaction is described.Figure optionsDownload as PowerPoint slide