کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1333251 | 979070 | 2010 | 8 صفحه PDF | دانلود رایگان |
Following different preparation routes, fenbufen has been intercalated in the interlayer space of layered double hydroxides with Mg2+ and Al3+ or Mg2+, Al3+ and Fe3+ in the layers. Well crystallized samples were obtained in most of the cases (intercalation was not observed by reconstruction of the MgAlFe matrix), with layer heights ranging between 16.1 and 18.8 Å. The presence of the LDH increases the solubility of fenbufen, especially when used as a matrix. The dissolution rate of the drug decreases when the drug is intercalated, and is even lower in those systems containing iron; release takes place through ionic exchange with phosphate anions from the solution. Preparation of microspheres with Eudragit® S 100 leads to solids with an homogeneous, smooth surface with efficient covering of the LDH surface, as drug release was not observed at pH lower than 7.
LDHs containing Mg, Al, Fe increase fenbufen solubility, release takes place through ionic exchange with phosphate anions from the medium. Spherical solids with homogeneous, smooth surface are formed when using Eudragit® S 100, efficiently covering the LDH surface.Figure optionsDownload as PowerPoint slide
Journal: Journal of Solid State Chemistry - Volume 183, Issue 12, December 2010, Pages 3002–3009