کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1358581 981349 2016 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines
ترجمه فارسی عنوان
آلکالوئیدها از ochrocephala Oxytropis و فعالیت ضدتکثیری مشتقات sophoridine بر ضد رده های سلولی سرطان
کلمات کلیدی
ochrocephala Oxytropis؛ گیاه سمی؛ ضدتکثیری؛ مشتقات Sophoridine
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Ten alkaloids (1–10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11–16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1–16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 5, 1 March 2016, Pages 1495–1497
نویسندگان
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