کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1368485 981701 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Insights into the structure–activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety
ترجمه فارسی عنوان
نگاهی به رابطه ساختار و فعالیت ZJ-101 ترکیب ضدسرطان مشتق شده از superstolide محصول طبیعی دریایی: نقش حیاتی ایفا شده توسط اندوتوکسیک لاکتون trienyl کونژوگه
کلمات کلیدی
Superstolide آنالوگ. عامل ضدسرطان؛ رابطه ساختار فعالیت؛ طراحی دارو؛ سنتز نامتقارن
Superstolide A analog; Anticancer agent; Structure–activity relationship; Drug design; Asymmetric synthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Compound ZJ-101, a structurally simplified analog of the marine natural product superstolide A, was previously developed in our laboratory. In the subsequent structure–activity relationship study, two new analogs, ZJ-105 and ZJ-106, were designed and synthesized to probe the importance of the conjugated trienyl lactone moiety of the molecule by replacing the C2–C3 double bond in ZJ-101 with a single bond and switching the geometry of the C4–C5 double bond in ZJ-101 from Z to E, respectively. Biological evaluation showed that ZJ-105 completely loses antiproliferative activity whereas ZJ-106 is significantly less active against cancer cells in vitro than ZJ-101, suggesting that the conjugated trienyl lactone moiety of the molecule is critical for its anticancer activity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3411–3413
نویسندگان
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