کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1368488 981701 2016 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata
ترجمه فارسی عنوان
ترکیبات پلی فنل ضدالتهابی حاصل از Cissus pteroclada Hayata
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کلمات کلیدی
Cissus pteroclada Hayata؛ Bergenin؛ ضدالتهابی؛ NF-κB
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (compound 1), together with seven known polyphenolic compounds, were isolated from the stem of Cissus pteroclada Hayata. The structures of the 8 compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Moreover, the in vitro anti-inflammatory effects of compounds (1–8) in LPS-stimulated murine macrophage RAW 264.7 cells were also investigated. Our results revealed that compound 1 inhibited the production of pro-inflammatory mediators NO and PGE2 and the expression of NF-κB, TNF-α, IL-1β, iNOS and COX-2.

The structure of new bergenin derivative, bergenin-11-O-α-d-galactopyranoside (1) isolated from the stem of Cissus pteroclada Hayata has been determined by detailed spectroscopic analyses. The in vitro anti-inflammatory activity assay of the compounds 1–8 indicated that bergenin derivatives (1–4) exhibited significant anti-inflammatory effects via modulation of NF-κB activation.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3425–3428
نویسندگان
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