|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1368528||981701||2016||3 صفحه PDF||ندارد||دانلود رایگان|
A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond.
Graphical abstractA novel series of chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. The nematocidal activity was determined. Some of them exhibited good activity. Structure–activity relationship was carried out by docking.Figure optionsDownload full-size imageDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3626–3628