کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1368528 981701 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives
ترجمه فارسی عنوان
سنتز، فعالیت nematocidal و مطالعه اتصال جدید مشتقات کربوکسامیدی کایرال 1- (3-chloropyridin-2-ایل) -3- (trifluoromethyl) -1H-پیرازول-4-
کلمات کلیدی
Trifluoromethylpyrazole؛ کایرال زنجیره ای ؛ فعالیت Nematocidal؛ سنتز؛ داکینگ
Trifluoromethylpyrazole; Chiral chain; Nematocidal activity; Synthesis; Docking
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond.

Graphical abstractA novel series of chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. The nematocidal activity was determined. Some of them exhibited good activity. Structure–activity relationship was carried out by docking.Figure optionsDownload full-size imageDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3626–3628
نویسندگان
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