کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1368779 981726 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Total synthesis and cytotoxic activities of longamide B, longamide B methyl ester, hanishin, and their analogues
ترجمه فارسی عنوان
سنتز کل و فعالیت سیتوتوکسیک longamide B، longamide متیل B استر، hanishin و آنالوگ های آنها
کلمات کلیدی
NBS، ان-بروموسوکینیمید؛ RT، دمای اتاق. TFA، trifluoroacetate؛ TsOH، p تولوئن سولفونیک اسید؛
NBS, N-bromosuccinimide; rt, room temperature; TFA, trifluoroacetate; TsOH, p-toluenesulfonic acid; DCM, dichloromethane; THF, tetrahydrofuranLongamide B; Longamide B methyl ester; Hanishin; Total synthesis; Cytotoxic activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

The marine alkaloids, longamide B (1), longamide B methyl ester (2), hanishin (3), and a series of non-naturally occurring analogues were synthesized in an efficient manner from inexpensive commercially available dl-aspartic acid dimethyl ester. The cytotoxicities of these natural products (1–3) and their analogues (9–15) were evaluated against human lung adenocarcinoma (A549) and human prostate cancer (PC3) cells. This is the first evaluation of the cytotoxicities of these alkaloids in these cancer cell lines and it revealed that analogue 15 had comparable cytotoxic activity to its natural parent compound, (±)-hanishin (3). This study provides useful information for further structural modification of these alkaloids in order to develop novel antitumor agents.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 6–8
نویسندگان
, , , , , , , ,