|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1368786||981726||2016||3 صفحه PDF||ندارد||دانلود رایگان|
BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55Gag or CA, by means of surface plasmon resonance. The synthesized Biotin–BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55Gag or CA, suggesting that BMMP exerts its activity by a different mechanism.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 43–45