کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1369412 981778 2016 3 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety
ترجمه فارسی عنوان
سنتز و بررسی آزمایشگاهی ضدتکثیری دی سولفید نامتقارن جدید با تحمل اندوتوکسیک 1،3،4 oxadiazole
کلمات کلیدی
دی سولفید نامتقارن؛ 1،3،4 Oxadiazole؛ فعالیت ضدتکثیری
Nonsymmetrical disulfides; 1,3,4-Oxadiazole; Antiproliferative activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A series of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety were designed, synthesized and evaluated for their in vitro antiproliferative activities against SMMC-7721, Hela and A549 human cancer cell lines by CCK-8 assay. The preliminary bioassay results demonstrated that all tested compounds 7a–7o exhibited antiproliferation with different degrees, and some compounds showed better effects than positive control 5-fluorouracil against various cancer cell lines. Among these compounds, compound 7j showed significant antiproliferative activity against SMMC-7721 cells with IC50 value of 3.40 μM. Compound 7a displayed highly effective biological activity against Hela cells with IC50 value of 4.26 μM. Compound 7g exhibited the best inhibitory effect against A549 cells with IC50 value of 6.26 μM.

Graphical abstractA series of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety were synthesized and evaluated for their in vitro antiproliferative activities against SMMC-7721, Hela and A549 human cancer cell lines by CCK-8 assay. The bioassay results demonstrated that all tested compounds exhibited antiproliferation with different degrees, and some compounds showed better effects than positive control 5-fluorouracil against various cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 18, 15 September 2016, Pages 4414–4416
نویسندگان
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