کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369705 981787 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders
ترجمه فارسی عنوان
مهار کننده های لیپاز دی سیل گلیسرول در اختلالات نوروژنیک و متابولیکی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

2-Arachidonoylglycerol (2-AG) is an endocannabinoid that activates the cannabinoid receptors type 1 and 2. It also serves as an important lipid precursor for the eicosanoid signaling pathway. Consequently, 2-AG is involved in many physiological functions, including anxiety, food intake, inflammation, memory, pain sensation and neurotransmission. Diacylglycerol lipases (DAGLs) are the main biosynthetic enzymes for 2-AG and their role in several pathophysiological conditions is currently under investigation. In this Digest we review all DAGL inhibitors reported to date and their effects in preclinical models of neurodegeneration and metabolic disorders.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 16, 15 August 2016, Pages 3831–3837
نویسندگان
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