کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1370748 981828 2017 4 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Synthesis of an acromelic acid A analog-based 11C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction
ترجمه فارسی عنوان
سنتز اسید acromelic A-11C برچسب ردیاب PET مبتنی بر آنالوگ برای اکتشاف از محل عمل از اسید acromelic در القای آلوداینیا
کلمات کلیدی
اسید Acromelic؛ آلوداینیا؛ ردیاب PET
Acromelic acid A; Allodynia; PET tracer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A novel 11C-labeled PET (positron emission tomography) tracer, which was designed based on the (phenylthio)pyrrolidine derivative that can competitively block the acromelic acid A-induced allodynia, was synthesized. A protocol in which methylation by palladium-mediated coupling of the boronate derivative with [11C]CH3I and deprotection of the protected amino acid moiety are successively performed in one-pot within 5 min was established for the synthesis of the tracer. The tracer is potentially useful as a tool to investigate the mode of action of acromelic acid A in the induction of allodynia.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 7, 1 April 2011, Pages 2017–2020
نویسندگان
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