کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1371957 981860 2017 4 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Discovery of a new series of 5-HT1A receptor agonists
ترجمه فارسی عنوان
کشف یک سری جدید از آگونیست های گیرنده 5-HT1A
کلمات کلیدی
گیرنده 5-HT1A؛ آگونیست؛ 1،3-دیاکسولان؛ حسن انتخاب
5-HT1A receptor; Agonists; 1,3-Dioxolane; Selectivity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Starting from compounds previously identified as α1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting.

Graphical abstractA new series of 5-HT1A receptor agonists has been discovered. Compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting of the series.Figure optionsDownload full-size imageDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 6, 15 March 2010, Pages 2017–2020
نویسندگان
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