Simultaneous determination of ascorbic acid, acetaminophen and codeine based on multi-walled carbon nanotubes modified with magnetic nanoparticles paste electrode

• A spinel-structured ZnCrFeO4 magnetic nanoparticle was synthesized via sol–gel method.
• A novel sensor has been developed based on multi-walled carbon nanotubes modified with ZnCrFeO4 nanoparticles for AA, AC and CO.
• The influence of various foreign species on the determination of AA, AC and CO were investigated.
• The proposed electrode was very easy to fabricate and eco-friendly and 100% reusable for multiple time analysis.

Based on incorporating ZnCrFeO4 into multi-walled carbon nanotubes paste matrix (MWCNTs/ZnCrFeO4/CPE), a chemically modified electrode was prepared for the simultaneous determination of ascorbic acid (AA), acetaminophen (AC) and codeine (CO). The prepared electrode, MWCNTs/ZnCrFeO4/CPE, was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The MWCNTs/ZnCrFeO4/CPE showed an efficient electrocatalytic activity for the oxidation of AA, AC, and CO. The separations of the oxidation peak potentials for AA–AC and AC–CO were about 250 mV and 630 mV, respectively. The calibration curves obtained for AA, AC, and CO were in the ranges of 0.4–730.0 μmol L− 1, 0.1–368.0 μmol L− 1, and 0.3–250.0 μmol L− 1, respectively. The detection limits (S/N = 3) were 0.03 μmol L− 1, 0.009 μmol L− 1, and 0.01 μmol L− 1 for AA, AC, and CO, respectively. The method was also successfully employed as a selective, simple, and precise method to determinate AA, AC, and CO in pharmaceutical and biological samples.

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