Potentiometric sensor fabrication having 2D sarcosine memories and analytical features

Highlight
• A new, cheap and simple method has been improved for designing and preparation for sarcosine determination.
• We have proposed a molecular imprinted polymer (MIP) film for the detection of sarcosine.
• We have investigated the measurement of binding interaction of a sarcosine imprinted potentiometric sensor.

In this study, a simple, rapid and sensitive method based on novel molecular imprinted polymeric sensor has been developed and validated for the determination of prostate cancer metabolite biomarker. The molecularly imprinted polymer (MIP) has been synthesized by emulsion polymerization, using sarcosine as template molecule, methacryloylamido histidine (MAH) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linking agent. The performance of the developed sarcosine sensor has been evaluated, and the results have indicated that a sensitive potentiometric sensor has been fabricated. The sarcosine sensor has showed high-selectivity, shorter response time (< 2 min), wider linear range (10− 2–10− 6 mM), lower detection limit (1.35 × 10− 7 mM), and satisfactory long-term stability (> 5.5 months).

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