کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1428397 1509174 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Formulations for modulation of protein release from large-size PLGA microparticles for tissue engineering
چکیده انگلیسی


• Two triblock copolymers (PLGA–PEG1500–PLGA and PLGA–PEG1000–PLGA) were synthesized.
• Triblock copolymers have similar effects on the lysozyme release from PLGA microparticles.
• Triblock copolymers increased the total lysozyme release and shortened the release period.
• Increase in triblock copolymer mass was associated with higher release rate.
• Increase in triblock copolymer mass was associated with shorter release period.

In this study we present an approach to pre-program lysozyme release from large size (100–300 μm) poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles. This approach involved blending in-house synthesized triblock copolymers with a PLGA 85:15. In this work it is demonstrated that the lysozyme release rate and the total release are related to the mass of triblock copolymer present in polymer formulation. Two triblock copolymers (PLGA–PEG1500–PLGA and PLGA–PEG1000–PLGA) were synthesized and used in this study. In a like-for-like comparison, these two triblock copolymers appeared to have similar effects on the release of lysozyme. It was shown that blending resulted in the increase of the total lysozyme release and shortened the release period (70% release within 30 days). These results demonstrated that blending PLGA–PEG–PLGA triblock copolymer with PLGA 85:15 can be used as a method to pre-program protein release from microparticles. These microparticles with modulated protein release properties may be used to create microparticle-based tissue engineering constructs with pre-programmed release properties.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 47, 1 February 2015, Pages 230–236
نویسندگان
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