کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1528479 1511963 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and characterization of magnesium gluconate contained poly(lactic-co-glycolic acid)/chitosan microspheres
ترجمه فارسی عنوان
سنتز و مشخص نمودن منیزیم گلوکونات شامل میکروسرایهای پلی (اسید لاکتیک گلیکولیک اسید) / کیتوزان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد مواد الکترونیکی، نوری و مغناطیسی
چکیده انگلیسی


• Magnesium gluconate contained PLGA/chitosan microspheres were fabricated.
• In vitro release of magnesium ions was performed using Xylidyl Blue assay.
• Chitosan coated PLGA can significantly control the release of magnesium ions.
• Cellular compatibility was tested using adipose-derived stem cells and PC12 cells.
• The cells encounter acceptably low levels of damage in contact with microspheres.

The goal of this study was to fabricate and investigate the chitosan coated poly(lactic-co-glycolic acid) (PLGA) microspheres for the development of controlled release magnesium delivery system. PLGA based microspheres are ideal vehicles for many controlled release drug delivery applications. Chitosan is a naturally occurring biodegradable and biocompatible polysaccharide, which can coat the surface of PLGA to alter the release of drugs. Magnesium gluconate (MgG) was encapsulated in the PLGA and PLGA/chitosan microspheres by utilizing the double emulsion solvent evaporation technique for controlled release study. The microspheres were tested with respect to several physicochemical and biological properties, including morphology, chemical structure, chitosan adsorption efficiency, magnesium encapsulation efficiency, in vitro release of magnesium ions, and cellular compatibility using both human adipose-derived stem cells (ASCs) and PC12 cells. Chitosan coated PLGA microspheres can significantly control the release of magnesium ions compared to uncoated PLGA microspheres. Both coated and uncoated microspheres showed good cellular compatibility.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: B - Volume 203, January 2016, Pages 59–66
نویسندگان
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