A novel method for preparation of bare and poly(vinylpyrrolidone) coated superparamagnetic iron oxide nanoparticles for biomedical applications

• Fe3O4 nanoparticles were successfully prepared in aqueous medium.
• A new platform for surface coating of SPIONs was established.
• In situ coating of Fe3O4 nanoparticles with PVP was achieved.
• PVP coated SPIONs have proper size and magnetic properties.

Pure crystalline superparamagnetic iron oxide nanoparticles (SPIONs) of magnetite (Fe3O4) were prepared from an additive-free aqueous solution of iron(III) nitrate salt though a novel one-pot electrodeposition method. The prepared nanoparticles were characterized by XRD, IR and TEM. The SPIONs were further coated by poly(N-vinyl-2-pyrrolidone) during their deposition process. The coating of PVP on SPIONs was confirmed by FT-IR, DSC-TGA and DLS analyses. The proposed electrochemical route can be concluded as a great routine for the preparation of polymer-coated SPIONs for biomedical applications.

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