کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1785276 1023372 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sigma-1 receptor as a potential pharmacological target for the treatment of neuropathology
ترجمه فارسی عنوان
گیرنده سیگما-1 به عنوان یک هدف بالقوه دارویی برای درمان نوروپاتولوژی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک اتمی و مولکولی و اپتیک
چکیده انگلیسی

Sigma receptors are usually classified as a separate class of intracellular receptors. Among them the sigma-1 receptor has been the most studied regarding its pharmacological applications. This receptor with average or high affinity binds a wide range of chemical compounds of very different structural classes and a variety of therapeutic and pharmacological properties. The sigma-1 receptor is a trans-membrane protein placed in the endoplasmic reticulum (ER), which regulates the function of inositol-3-phosphate receptor, stabilizing the calcium signaling between ER and mitochondria. There are studies that the sigma-1 receptor is involved in the formation of many neurological and psychiatric conditions. It is assumed that the sigma-1 receptor acts as a sensor of normal calcium operation. The studies over the recent years have shown the role of the violation in calcium signaling in the pathogenesis of Alzheimer's and Huntington's diseases. In particular, changes in calcium homeostasis of the endoplasmic reticulum lead to the break of synaptic connections in the neurons. Thus, the sigma-1 receptor holds promise in application as a potential therapeutic target for the treatment of neuropathological diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: St. Petersburg Polytechnical University Journal: Physics and Mathematics - Volume 2, Issue 1, March 2016, Pages 31–40
نویسندگان
, , , , , ,