کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1875793 1532098 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preclinical evaluation of 99mTc labeled gefitinib as a potential scintigraphic probe for the detection of tumors expressing epidermal growth factor receptors
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Preclinical evaluation of 99mTc labeled gefitinib as a potential scintigraphic probe for the detection of tumors expressing epidermal growth factor receptors
چکیده انگلیسی


• Gefitinib – an epidermal growth factor receptor inhibitor was successfully radiolabeled with 99mTc and the resultant radiolabel 99mTc-gefitinib had high radiolabeling efficiency and in vitro stability.
• The radiotracer cleared from blood bi-exponentially.
• Animal organ biodistribution data demonstrated hepato-renal excretion of the radiotracer.
• Gamma camera imaging in tumor bearing mice demonstrated that the radiotracer accumulated in the tumor site with high target to non target ratio.
• The diagnostic efficacy of 99mTc-gefitinib needs clinical validation in tumors expressing high EGFR density.

In the present study, we successfully radiolabeled gefitinib with 99mTc by direct labeling method. The radio-ligand had radiolabeling efficiency of >95.0% and in vitro stability of >80.0% at 24 h. The radiotracer cleared from blood bi-exponentially. Animal organ biodistribution data indicated hepato-renal excretion of the radiotracer. Scintigraphy carried out in tumor bearing mice (induced by EGFR expressing EAT cell lines) demonstrated that the radiotracer accumulated in the tumor site with T/NT ratio of 3.3±0.2 at 1 h.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 99, May 2015, Pages 41–45
نویسندگان
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