Drug delivery system design and development for boron neutron capture therapy on cancer treatment

• Herein, we have synthesized boron-modified diblock copolymer.
• Bpin-PLA-PEOz, which will be served as new boron containing vehicle for transporting the boron drug.
• This boron containing Bpin-PLA-PEOz micelle was low toxicity can be applied to drug delivery.

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.