کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902671 1534425 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients
ترجمه فارسی عنوان
دلیریم یک عامل خطر برای کاهش شناختی بیشتر در بیماران مبتلا به شکستگی لگن اختلال شناختی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Delirium is frequent among hip fracture patients with known dementia.
• The most cognitively impaired patients were delirious already before the operation.
• Delirium was associated with a faster progression of cognitive decline.

BackgroundDelirium is a risk factor for dementia in cognitively intact patients. Whether an episode of delirium accelerates cognitive decline in patients with known dementia, is less explored.MethodsThis is a prospective follow-up study of 287 hip fracture patients with pre-fracture cognitive impairment. During the hospitalization, the patients were screened daily for delirium using the Confusion Assessment Method. Pre-fracture cognitive impairment was defined as a score of 3.44 or higher on the pre-fracture Informant Questionnaire on Cognitive Decline in the Elderly Short Form (IQCODE-SF). At follow-up after 4–6 months, the caregivers rated cognitive changes emerging after the fracture using the IQCODE-SF, and the patients were tested with the Mini Mental State Examination (MMSE). A sub-group of the patients had a pre-fracture MMSE score which was used to calculate the yearly decline on the MMSE in patients with and without delirium.Results201 of the 287 patients developed delirium in the acute phase. In linear regression analysis, delirium was a significant and independent predictor of a more prominent cognitive decline at follow-up measured by the IQCODE-SF questionnaire (p = 0.002). Among patients having a pre-fracture MMSE score, the patients developing delirium had a median (IQR) yearly decline of 2.4 points (1.1–3.9), compared to 1.0 points (0–1.9) in the group without delirium (p = 0.001, Mann–Whitney test).ConclusionsHip fracture patients with pre-fracture dementia run a higher risk of developing delirium. Delirium superimposed on dementia is a significant predictor of an accelerated further cognitive decline.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 64, May–June 2016, Pages 38–44
نویسندگان
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