کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1912964 1535094 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage
ترجمه فارسی عنوان
نقش گالککتین 3 در پلاسما به عنوان بیومارکر پیش بینی شده پس از خونریزی داخل حاد کبدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Plasma galectin-3 levels are elevated after intracerebral hemorrhage.
• Plasma galectin-3 levels are highly associated with injury severity.
• Plasma galectin-3 levels independently predict clinical outcomes.
• Plasma galectin-3 levels have high prognostic predictive values.

ObjectiveInflammation is involved in pathophysiological mechanisms underlying secondary brain injury after intracerebral hemorrhage. Enhanced circulating levels of galectin-3, a proinflammatory cytokine, have close relation to poor prognosis of some inflammatory illnesses. This study was designed to investigate whether plasma galectin-3 levels are related to the inflammation, severity and prognosis following intracerebral hemorrhage.MethodsIn this observational, prospective study, plasma galectin-3 levels of 110 patients and 110 controls were determined. We further assessed the association of galectin-3 levels with inflammation reflected by systemic C-reactive protein levels, severity indicated by hematoma volumes and National Institutes of Health Stroke Scale (NIHSS) scores, and endpoints including 1-week mortality, 6-month mortality, 6-month overall survival and 6-month unfavorable outcome (modified Rankin Scale score > 2).ResultsPlasma galectin-3 levels of patients were significantly higher than those of controls. Galectin-3 was identified as an independent prognostic predictor for 1-week mortality, 6-month mortality, 6-month overall survival and 6-month unfavorable outcome, as well as had strong relation to C-reactive protein levels, hematoma volumes and NIHSS scores. Compared with NIHSS scores and hematoma volumes, plasma galectin-3 levels had similar areas under receiver operating characteristic curve (AUC). Moreover, galectin-3 levels significantly improved AUCs of NIHSS scores or hematoma volumes alone for prediction of 6-month mortality and 6-month unfavorable outcome.ConclusionsElevated plasma galectin-3 levels are strongly associated with the inflammation, severity and poor prognosis after intracerebral hemorrhage, indicating galectin-3, involved in brain inflammation, might have the potential to be a prognostic biomarker for hemorrhagic stroke.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 368, 15 September 2016, Pages 121–127
نویسندگان
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