کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1912991 1535094 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differentiation of cancer from atrial fibrillation in patients with acute multifocal stroke
ترجمه فارسی عنوان
تمايز سرطان از فيبريلاسيون دهليزي در بيماران مبتلا به سکته مغزي چند ساله حاد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Cancer is serious cause of embolic infarction with undetermined source.
• D-dimer levels were higher in cancer-related embolic infarction than in Af alone.
• The differential D-dimer value of cancer-related infarction was 2.0 μg/mL.
• D-dimer levels during the sub-acute phase were elevated in many cancer patients.

ObjectiveAcute multifocal embolic infarction (AMEI) is conventionally caused by etiologies such as cardioembolism due to atrial fibrillation (Af), but can also be caused by serious underlying diseases such as cancer. We characterized cancer-related AMEI and identified useful indicators for cancer-associated strokes.MethodsA retrospective analysis was performed on 35 patients with Af-related AMEI and 35 patients with cancer-related AMEI selected from 1235 consecutive patients with acute infarcts. All patients received diffusion-weighted magnetic resonance (MR) imaging. Cerebral MR angiography, carotid and cardiac ultrasonography, electrocardiogram-monitoring and whole body computed tomography were also performed on these patients. D-dimer levels were evaluated on admission, and were measured during the sub-acute phase in 19 of the patients with Af and 27 of the patients with cancer.ResultsAcute phase D-dimer levels were significantly higher in patients with cancer than in patients with Af alone. The cut-off D-dimer value to identify cancer-associated infarcts was 2.0 μg/mL. D-dimer levels during the sub-acute phase remained elevated in the cancer patients.ConclusionsWe may differentiate cancer-associated AMEI from Af using a D-dimer level ≥ 2.0 μg/mL, which does not decrease during the sub-acute phase.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 368, 15 September 2016, Pages 344–348
نویسندگان
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