|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1920410||1535825||2016||3 صفحه PDF||سفارش دهید||دانلود کنید|
• Impact of WMH has been studied, with variable results reported between lesions and motor function.
• There is agreement on a direct correlation between WMH volume, and motor and gait impairment.
• Deep WMH are associated with worse response to l-Dopa for axial impairment.
ObjectiveTo determine whether brain white matter hyperintensities (WMH) influence l-dopa response in Parkinson's disease (PD) patients.MethodsWe prospectively evaluated 60 PD patients with an acute l-dopa challenge test, and assessed motor performance with the Movement Disorders Society revised Unified Parkinson's Disease Rating Scale (MDS-UPDRS) during “ON” and “OFF” medication states. Magnetic resonance images were examined using a visual semi-quantitative rating scale for quantification and distribution analysis of WMH. l-dopa challenge test response was correlated to extent and location of WMH, to determine a potential association between them.ResultsSubjects with greater deep WMH burden, showed less response to l-dopa on axial motor symptoms (R = −0.35; p < 0.027), when tested with Part III of the MDS-UPDRS before and after acute levodopa challenge.ConclusionsResults suggest WMH may affect response to l-dopa on axial function of PD patients, which could be due to either non-dopaminergic (cortico-basal ganglia) motor pathway disruption, or postsynaptic nigrostriatal pathway involvement.
Journal: Parkinsonism & Related Disorders - Volume 24, March 2016, Pages 126–128