کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1950518 | 1055655 | 2015 | 10 صفحه PDF | دانلود رایگان |
• SYK can have both tumor promoting and tumor suppressing activity.
• SYK promotes cell survival in multiple tumor types.
• SYK inhibits motility and metastasis in many invasive carcinomas.
• SYK alters cellular differentiation programs that regulate EMT.
SYK (spleen tyrosine kinase) is well-characterized in the immune system as an essential enzyme required for signaling through multiple classes of immune recognition receptors. As a modulator of tumorigenesis, SYK has a bit of a schizophrenic reputation, acting in some cells as a tumor promoter and in others as a tumor suppressor. In many hematopoietic malignancies, SYK provides an important survival function and its inhibition or silencing frequently leads to apoptosis. In cancers of non-immune cells, SYK provides a pro-survival signal, but can also suppress tumorigenesis by restricting epithelial–mesenchymal transition, enhancing cell–cell interactions and inhibiting migration.
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Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1853, Issue 1, January 2015, Pages 254–263