Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

• Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria.
• Antioxidant and anti-inflammatory activities are crucial properties of Coenzyme Q10.
• Coenzyme Q10 can make the efficacy of conventional therapy of heart failure better.
• Hypertension patients may benefit from Coenzyme Q10 supplementation.
• Coenzyme Q10 supplementation could improve endothelial function.

Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated.