Adipocytokines, inflammatory and oxidative stress markers of clinical relevance altered in young overweight/obese subjects

• ADA and DPP-IV are relevant clinical in young obese individuals.
• IL-6 could be a marker of future insulin resistance in obese youths.
• Adiposity predisposes to changes in adipocytokines, inflammatory and oxidative markers.
• Resistin, RBP-4, adiponectin may be related to cardiometabolic events in adulthood.
• Few data are available about the prognostic role of adipocytokines in obese youths.

ObjectiveThe aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers.Design and methodsCross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese).Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power — FRAP) were measured.ResultsObese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters.ConclusionsThis analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, and may contribute development of the pathways involved in obesity. These findings may hold promise in identifying new inflammatory markers, benchmarks that assist in the diagnosis and monitoring of patients with overweight and obese.