کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1993552 1064680 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted endoradiotherapy using nucleotides
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Targeted endoradiotherapy using nucleotides
چکیده انگلیسی

Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the α and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.


► Molecular targeting of proliferation.
► Radionuclides for internal radiotherapy.
► Radiation effects of radionuclide microirradiation with respect to DNA.
► Nucleosides for therapy.
► Perspective for the clinical use.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 55, Issue 3, November 2011, Pages 203–214
نویسندگان
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