کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006100 1541722 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents
ترجمه فارسی عنوان
کاربردهای بالقوه درمانی پپتیدهای دفاع چندملیتی از پوست قارچ به عنوان داروهای ضد سرطان، ضد ویروسی، ایمن سازی و ضد دیابتی
کلمات کلیدی
پپتید دفاع میزبان، پوست قورباغه، ضد سرطان، ضد ویروسی، ایمونوادولوژیک، دیابت نوع 2
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• The therapeutic potential of frog skin peptides as anti-infective agents has not been realized.
• Cytotoxic peptides show potential as anti-cancer and anti-viral agents.
• Certain peptides stimulate production of pro- and anti-inflammatory cytokines.
• Such peptides may act as anti-inflammatory, immunosuppressive, or immunostimulatory agents.
• Peptides that stimulate insulin release show potential in Type 2 diabetes therapy.

Frog skin constitutes a rich source of peptides with a wide range of biological properties. These include host-defense peptides with cytotoxic activities against bacteria, fungi, protozoa, viruses, and mammalian cells. Several hundred such peptides from diverse species have been described. Although attention has been focused mainly on antimicrobial activity, the therapeutic potential of frog skin peptides as anti-infective agents remains to be realized and no compound based upon their structures has yet been adopted in clinical practice. Consequently, alternative applications are being explored. Certain naturally occurring frog skin peptides, and analogs with improved therapeutic properties, show selective cytotoxicity against tumor cells and viruses and so have potential for development into anti-cancer and anti-viral agents. Some peptides display complex cytokine-mediated immunomodulatory properties. Effects on the production of both pro-inflammatory and anti-inflammatory cytokines by peritoneal macrophages and peripheral blood mononuclear cells have been observed so that clinical applications as anti-inflammatory, immunosuppressive, and immunostimulatory agents are possible. Several frog skin peptides, first identified on the basis of antimicrobial activity, have been shown to stimulate insulin release both in vitro and in vivo and so show potential as incretin-based therapies for treatment of patients with Type 2 diabetes mellitus. This review assesses the therapeutic possibilities of peptides from frogs belonging to the Ascaphidae, Alytidae, Pipidae, Dicroglossidae, Leptodactylidae, Hylidae, and Ranidae families that complement their potential role as anti-infectives for use against multidrug-resistant microorganisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 57, July 2014, Pages 67–77
نویسندگان
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